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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Nov 14;108:68–82. doi: 10.1016/j.addr.2016.11.001

Figure 5.

Figure 5

Compressive hydrogel systems. (a) Schematic representation of dexamethasone-encapsulated micelles (xBCM(DEX)) crosslinked to hyaluronic acid-based matrix (HAGMA). (b) Mechanical stimulation (top) and resulting release profile (bottom) from xBCM(DEX) crosslinked to HAGMA. (c) Mechanical stimulation (top) and corresponding release (middle) and cumulative release (bottom) of FITC encapsulated in chitosan-alginate layers with silica nanoparticles (1L–HHC) compared to chitosan-alginate layers (control). Release is modulated by force applied (d) and addition of more layers (e). Figures are reprinted with permission from Refs. [108] and [109]