Table 3.
Summary of Patients With Subsequent Ipsilateral Breast Carcinoma (Invasive Carcinoma or DCIS).
| Characteristics | Case 1 | Case 2 | Case 3 | Case 4 |
|---|---|---|---|---|
| Clinical | ||||
| Age (years) at diagnosis of ADH/DCIS | 48 | 42 | 52 | 83 |
| Menopausal status | Premenopausal | Premenopausal | Postmenopausal | Postmenopausal |
| Family history of breast cancer | Yes, second degree | No | No | Yes, first degree |
| Indication for biopsy | Calcifications | Calcifications | MRI abnormality | Calcifications |
| Adjuvant therapy | None | None | None | None |
| Pathological | ||||
| ADH/DCIS diagnosis | Core biopsy only | Core biopsy only | Excision | Core biopsy only |
| ADH/DCIS size, mm | 2 | 1 | 2 | 1 |
| No. of ducts involved | >2 | >2 | >2 | 2 |
| Predominant architecture | Flat | Micropapillary | Cribriform | Micropapillary |
| Nuclear grade | 1–2 | 1 | 1–2 | 1 |
| Classic LCIS or ALH | Yes | No | Yes | No |
| Final margin status | Negative | Negative | Negative | Negative |
| Consensus diagnosis | ADH | ADH | ADH | ADH |
| Interobserver agreement | 3 of 5 | 4 of 5 | 4 of 5 | 4 of 5 |
| Subsequent ipsilateral breast carcinoma | ||||
| Interval, years | 3 | 10 | 4 | 1 |
| Histology | DCIS | DCIS | Invasive ductal | Invasive ductal ca with focal mucin |
| Site in relation to ADH/DCIS | Same quadrant | Same quadrant | Same quadrant | Different quadrant |
| Histological grade | Not applicable | Not applicable | III | III |
| Nuclear grade | High | Intermediate | II | II |
| Size, cm | 0.8 | Not available | 1.2 | 2 |
| Receptor status | Not available | ER+ | ER+, PR−, HER2− | ER+, PR+, HER2− |
Abbreviations: ADH, atypical ductal hyperplasia; ALH, atypical lobular hyperplasia; DCIS, ductal carcinoma in situ; LCIS, lobular carcinoma in situ; MRI, magnetic resonance imaging.