Table 3.
Characteristics | Case 1 | Case 2 | Case 3 | Case 4 |
---|---|---|---|---|
Clinical | ||||
Age (years) at diagnosis of ADH/DCIS | 48 | 42 | 52 | 83 |
Menopausal status | Premenopausal | Premenopausal | Postmenopausal | Postmenopausal |
Family history of breast cancer | Yes, second degree | No | No | Yes, first degree |
Indication for biopsy | Calcifications | Calcifications | MRI abnormality | Calcifications |
Adjuvant therapy | None | None | None | None |
Pathological | ||||
ADH/DCIS diagnosis | Core biopsy only | Core biopsy only | Excision | Core biopsy only |
ADH/DCIS size, mm | 2 | 1 | 2 | 1 |
No. of ducts involved | >2 | >2 | >2 | 2 |
Predominant architecture | Flat | Micropapillary | Cribriform | Micropapillary |
Nuclear grade | 1–2 | 1 | 1–2 | 1 |
Classic LCIS or ALH | Yes | No | Yes | No |
Final margin status | Negative | Negative | Negative | Negative |
Consensus diagnosis | ADH | ADH | ADH | ADH |
Interobserver agreement | 3 of 5 | 4 of 5 | 4 of 5 | 4 of 5 |
Subsequent ipsilateral breast carcinoma | ||||
Interval, years | 3 | 10 | 4 | 1 |
Histology | DCIS | DCIS | Invasive ductal | Invasive ductal ca with focal mucin |
Site in relation to ADH/DCIS | Same quadrant | Same quadrant | Same quadrant | Different quadrant |
Histological grade | Not applicable | Not applicable | III | III |
Nuclear grade | High | Intermediate | II | II |
Size, cm | 0.8 | Not available | 1.2 | 2 |
Receptor status | Not available | ER+ | ER+, PR−, HER2− | ER+, PR+, HER2− |
Abbreviations: ADH, atypical ductal hyperplasia; ALH, atypical lobular hyperplasia; DCIS, ductal carcinoma in situ; LCIS, lobular carcinoma in situ; MRI, magnetic resonance imaging.