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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Exp Neurol. 2016 Dec 22;289:64–72. doi: 10.1016/j.expneurol.2016.12.008

Fig. 7. Effects of galanin receptor blockers administered in the locus coeruleus on serotonergic and noradrenergic transmission.

Fig. 7

The strength of noradrenergic tone in LC-PFC and of serotonergic tone in RN-PFC in LC-PFC are shown in the same animals as in Fig. 6. A. Effects on noradrenergic transmission. In epileptic “impulsive” rats, blockade of LC GalR1/GalR2 (M40) significantly strengthened noradrenergic tone, although it remained weaker than in naïve subjects. Blockade of GalR2 (M871) had no effect on the examined parameter. Neither of the GalR blockers modified noradrenergic transmission in animals of other groups. B. Effects on serotonergic transmission. Neither of the treatments had any effects on serotonergic tone in animals of all groups. Data are presented as Mean±SEM. *-p<0.05 vs. Naïve in the same treatment; †- p<0.05 vs. respective category of Saline-treated rats. Two-Way ANOVA plus Tukey’s multiple comparisons test. Noradrenergic transmission: Interaction F (6, 51) = 2.116, p = 0.0674; treatment factor F (2, 51) = 2.073, p = 0.1363; behavior factor F (3, 51) = 38.83, p < 0.0001. Serotonergic transmission: Interaction F (6, 51) = 0.8145, p = 0.5637; treatment F (2, 51) = 1.107, p = 0.3382; behavior factor F (3, 51) = 31.24, p< 0.0001.