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. 2017 Jan 4;6(1):e3. doi: 10.1038/emi.2016.132

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Phylogenetic analysis of the HCoV-OC43 strains based on the full-length genome. Trees were reconstructed using the neighbor-joining method and Kimura 2-parameter model in MEGA 6.0. Bootstrap values were calculated from 1000 trees. Bootstrap values >70% were indicated on the branch nodes. The scale bar of an individual tree indicates the substitutions per site. (B) Estimation of pairwise genetic distances between HCoV-OC43 genotypes based on the full-length genome sequences. Genotypes F and G were previously classified as lineages 1 and 2, respectively.²⁰