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. Author manuscript; available in PMC: 2017 Dec 23.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Nov 24;55(52):16039–16043. doi: 10.1002/anie.201609043

Figure 2.

Figure 2

In vivo behaviors of ultrasmall glutathione coated metal nanoparticles. A) Renal clearance of four kinds of metal NPs within 48 h p.i.. B) The exponential relationship between 2-h renal clearance (RC) and particle core density (d), expressed as: RC=2.5*103exp(−d/2.1)+29.9 R2=0.98 C) Pharmacokinetics of the NPs. The pharmacokinetic parameters were determined by fitting the data with a two-compartment model. D–F) The relationships between the density and the three main pharmacokinetic parameters: volume of distribution (Vd and the relationship can be expressed as: Vd=4.31*exp(−d /0.51)+13.3 R2=0.99 (D), clearance (CL) and the relationship can be expressed as follow: CL =6.55*exp(−d /0.43)+0.55 R2=0.99 (E) and area under the curve (AUC) and the relationship can be expressed as: AUC=2.7*105exp(−d/0.88)+2.5, R2=0.99 (F), were calculated. G) The relationship between tumor accumulation (TA) and density which can be expressed as: TA=0.16d−0.87, R2=0.99.