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. Author manuscript; available in PMC: 2017 Dec 23.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Nov 24;55(52):16039–16043. doi: 10.1002/anie.201609043

Figure 3.

Figure 3

Fluorescence imaging of renal clearance of GS-AuNPs and GS-AgNPs. A,B) Representative whole-body noninvasive fluorescence images of mice injected with the GS-AuNPs (A) and the GS-AgNPs (B) (Ex/Em filters: 710/830 nm). C,D) Representative time-fluorescence intensity curves (TFICs) of kidneys (C) and background (D) in the two groups of BALB/c mice (n=3) intravenously injected with GS-AuNPs and GS-AgNPs, respectively. Two parameters were extracted from the kidney TFICs: time to achieve maximum fluorescence intensity (TMFI) and clearance rate (defined as the clearance percentage at 60 min=[(peak value-intensity at 60 min) / peak value] × 100%). E–G) Kidney penetration study. Bright field (BF) and Fluorescence images of kidney slices after iv injection of PBS, GS-AuNPs and GS-AgNPs. Three representative regions were selected: cortex (E), medulla regions near the artery (F) and pelvis (G). scale bar=200 μm.