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. Author manuscript; available in PMC: 2017 Dec 23.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Nov 24;55(52):16039–16043. doi: 10.1002/anie.201609043

Figure 4.

Figure 4

The biodistribution study of GS-AuNPs and GS-AgNPs. A) 7-min biodistribution of GS-AgNPs and GS-AuNPs in major organs. B) The differences in the clearance of GS-AuNPs (ΔGS-AuNPs) and clearance of GS-AgNPs (ΔGS-AgNPs) in various organs at 7 min and 48 h p.i.. (Kd: kidney, It: intestine, Lv: liver, Hr: heart, Sk: skin, Ms: muscle, St: stomach, Sp: spleen; %ID/g=percentage of the injected dose per gram of tissues). *p<0.005. C) A hypothesized scheme showing the margination of GS-AuNPs (yellow) and GS-AgNPs (green) circulating in the blood stream after tail injection. Due to density-dependent margination, GS-AgNPs reach the kidneys faster than GS-AuNPs.