Table 2.

Increase in IsoPs between 14 and 28 days is associated with worse neurodevelopmental scores at 12 months of corrected age

Outcome	Model	OR	95% Cl	P-value
(a) ORs for higher scores per 50-unit increase in IsoP
Cognition	Unadjusted	0.74	(0.62 to 0.88)	<0.001
Communication	Unadjusted	0.81	(0.69 to 0.95)	0.010
Motor	Unadjusted	0.75	(0.64 to 0.88)	<0.001
Cognition	Adjusted	0.72	(0.59 to 0.88)	0.001
Communication	Adjusted	0.81	(0.68 to 0.97)	0.026
Motor	Adjusted	0.69	(0.57 to 0.84)	<0.001
Outcome	Model	Score change in points	Cl	P-value
(b) Predicted change in DAYC scores per 50-unit increase in IsoP
Cognition	Unadjusted	− 1.81	(−2.77 to − 0.85)	<0.001
Communication	Unadjusted	− 1.05	(−1.93 to − 0.16)	0.010
Motor	Unadjusted	− 2.18	(−3.20 to − 1.17)	<0.001
Cognition	Adjusted	− 1.87	(−2.95 to − 0.79)	0.001
Communication	Adjusted	− 1.05	(−1.05 to − 0.07)	0.026
Motor	Adjusted	− 2.30	(−3.43 to − 1.17)	<0.001

Abbreviations: CI, confidence interval; DAYC, Developmental Assessment of Young Children; IsoP, F2-isoprostane; OR, odds ratio.