. Author manuscript; available in PMC: 2017 Feb 1.

Published in final edited form as: J Perinatol. 2016 May 12;36(9):779–783. doi: 10.1038/jp.2016.74

Table 3.

Mediation analysis

Outcome (DAYC)	Direct IsoP effect (ADE)	95% Cl	RSI-mediated effect (ACME)	95% Cl	Proportion of IsoP effect mediated by RSI
Cognitive	− 1.5	(−3.1 to − 0.5)^**	− 0.3	(−0.7 to 0.04)	0.16
Communication	− 0.06	(−1.6 to 0.5)	− 0.4	(−0.9 to − 0.05)^*	0.4
Motor	− 1.7	(−3.1 to − 0.4)^*	− 0.58	(−1.2 to − 0.09)^*	0.25^*

Abbreviations: ACME average causal mediation effect; ADE, average direct effect; CI, confidence interval; DAYC, Developmental Assessment of Young Children; IQR, interquartile range (25th–75th); IsoP effect, effect of the change in F2-isoprostane levels between 14 and 28 days; RSI, Respiratory Severity Index (fractional inspired oxygen received (FiO₂) × mean airway pressure (MAP) or flow).

P ≤0.05;

^**

P ≤0.01.