Table 3.
Modulation of activity‐induced pHcyto acid transients in motorneuron terminals by drugs which target acid transporters varies between larvae with different DVGLUT expression levels
| Genotype | ||||||||
|---|---|---|---|---|---|---|---|---|
| w1118 | dvglut1/dvglut2 | UAS‐dvglut | ||||||
| Treatment | Value | Mean ± SEM | n | Mean ± SEM | n | Mean ± SEM | n | F DF |
| pHrest | ||||||||
| Veh. | 7.37 ± 0.04 | 8 | 7.21 ± 0.04 | 6 | 7.42 ± 0.01 | 7 | 10.311(2,18) * | |
| BafA1 | 7.17 ± 0.04 | 6 | 7.14 ± 0.10 | 6 | 7.25 ± 0.02 | 6 | 0.892(2,15) | |
| BafA1+EB | 7.13 ± 0.02 | 6 | 7.11 ± 0.06 | 6 | 7.19 ± 0.03 | 9 | 1.193(2,18) | |
| BafA1+EB+EIPA | 7.07 ± 0.01 | 6 | 7.08 ± 0.03 | 7 | 7.11 ± 0.04 | 6 | 0.496(2,15) | |
| τrec (s) | ||||||||
| Veh. | 30.3 ± 5.81 | 8 | 30.4 ± 9.11 | 6 | 22.7 ± 3.74 | 7 | 6.449(2,18) * | |
| BafA1 | 31.1 ± 2.75 | 6 | 36.9 ± 7.73 | 6 | 27.8 ± 2.90 | 6 | 0.342(2,15) | |
| BafA1+EB | 31.1 ± 2.75 | 6 | 36.9 ± 7.73 | 6 | 27.8 ± 2.90 | 9 | 1.027(2,18) | |
| BafA1+EB+EIPA | 50.0 ± 4.61 | 6 | 51.4 ± 4.17 | 7 | 53.7 ± 5.62 | 6 | 0.143(2,15) | |
| JH+ (mm s–1) | ||||||||
| Veh. | –0.53 ± 0.05 | 8 | –0.68 ± 0.05 | 6 | –0.35 ± 0.01 | 7 | 14.833(2,18) * | |
| BafA1 | –1.19 ± 0.07 | 6 | –1.66 ± 0.26 | 6 | –1.01 ± 0.05 | 6 | 4.480(2,15) * | |
| BafA1+EB | –1.68 ± 0.04 | 6 | –1.68 ± 0.17 | 6 | –1.76 ± 0.08 | 9 | 0.218(2,18) | |
| BafA1+EB+EIPA | –2.09 ± 0.07 | 6 | –2.25 ± 0.13 | 7 | –1.92 ± 0.10 | 6 | 2.259(2,15) | |
* P < 0.050 as determined by one‐way ANOVA.