Figure 1. Regulation of skeletal muscle lipid synthesis during altered states of metabolism.

Acyl‐CoA synthetase (ACSL) 6 drives acyl coenzyme A (acyl‐CoA) toward lipid synthesis, while other acyl‐CoA‐synthetases (ACSL 1 or 5) drive lipid oxidation or energy expenditure, respectively. Specifically, acute high fat feeding promotes ACSL6 expression, whereas fasting or chronic aerobic exercise training downregulates gene expression of ACSL6 and markers of lipid synthesis.