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. 2016 Oct 10;595(3):919–934. doi: 10.1113/JP272683

Figure 6. Synchronous synaptic transmission at 400 Hz is rescued by manipulations that decrease intraterminal calcium.

Figure 6

A and B, eEPSCs in response to 400 Hz stimulus trains after treatment with EGTA‐AM in mature (A) and old (B) mice. Top: single trial; bottom: average trace of 10 trials; inset: expanded view of the last eEPSCs from the dashed box in the top trace. Ticks above the trace mark stimulation times. Plots in C and D are arranged in the same format. C and D, eEPSCs in response to 400 Hz stimulus trains after bath application of 25 nm ω‐agatoxin IVA in mature (C) and old (D) mice. E, normalized eEPSC peak amplitude to the first eEPSC throughout the stimulus trains at 400 Hz. F, fraction of asynchronous release charge throughout the 50‐pulse trains at 400 Hz. EGTA: EGTA‐AM treatment; Aga: ω‐agatoxin IVA treatment. Data in E and F are shown as mean ± SEM.