Table 4.
Linear ERR per Gy by age at exposure (AE).1
| Outcome | Fixed Lag (years) | ERR per Gy (90% CI)2 by AE (years) | Heterogeneity (LRT p-value, 2 df)3 | ||
|---|---|---|---|---|---|
|
| |||||
| <35 | 35<50 | 50+ | |||
| All solid cancers | 10 | -0.64 (-1.4, 0.19) | 0.75 (0.23, 1.32) | 0.51 (-0.15, 1.23) | 0.086 |
| MN trachea, bronchus and lung | 10 | -1.44 (-2.70, 0.05) | 0.97 (0.06, 2.00) | 0.68 (-0.46, 2.00) | 0.093 |
| Leukemia excl. CLL | 2 | 5.29 (-0.19, 12.45) | -0.29 (-3.17, 3.30) | 6.16 (1.89, 11.9) | 0.213 |
| Acute myeloid leukemia | 2 | 6.36 (-0.35, 15.93) | -2.36 (-5.68, 2.35) | 2.77 (-1.76, 10.07) | 0.292 |
| Chronic myeloid leukemia | 2 | 6.84 (-6.30, 31.15) | 9.33 (-0.58, 25.54) | 17.1 (2.61, 43.48) | 0.788 |
| Multiple myeloma | 2 | -3.30 (-8.71, 4.57) | 1.52 (-2.15, 6.28) | 3.22 (-2.03, 10.73) | 0.472 |
| Hodgkin lymphoma | 10 | NC | NC | NC | NC |
| Non Hodgkin lymphoma | 10 | 3.03 (-1.38, 8.47) | 1.42 (-1.17, 4.50) | -1.59 (NC, 1.74) | 0.299 |
1
Extrapolating estimates to 1Gy resulted in artefactual values (i.e., ERR per Gy <-1) for some outcomes. These estimates are shown for completeness only.
2
Profile-likelihood confidence intervals calculated with 1 df.
3
Compared to a model where all parameters are equal, which is equivalent to the baseline lag model.
Abbreviations: CI, confidence interval; CLL, chronic lymphocytic leukemia; df, degrees of freedom; ERR, excess relative risk; LRT, likelihood ratio test; MN, malignant neoplasm; NC, not-calculable.