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. 2017 Feb 1;7:41376. doi: 10.1038/srep41376

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Copyright © 2017, The Author(s)

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Effects of retinoids on the DPH (a,b) and TMA-DPH (c,d) fluorescence anisotropies in Pgp⁺ and Pgp⁻ NIH 3T3 cells (a,c), and ABCG2 expressing and non-expressing MDCK cells (b,d). Cells were pre-treated with retinoids applied at 100 μM concentration or transporter inhibitors (10 μM cyclosporin (for Pgp) or 2 μM Ko143 (for ABCG2)) for 10 min at 37 °C and then further incubated with 2 μM DPH or TMA-DPH for another 20 min at room temperature. Fluorescence anisotropy values were measured at 37 °C. (*significant difference compared to control, ^†significant difference between drug-sensitive and -resistant cells (n = 3, mean ± SD, ANOVA, Holm-Sidac post-hoc analysis, P < 0.05)).