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. 2017 Feb 1;7:41376. doi: 10.1038/srep41376

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Copyright © 2017, The Author(s)

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Changes of apparent K_M and v_max values of the Pgp- (a–d) and ABCG2-mediated (e–h) ATPase activity in response to retinol and 13-cis-retinoic acid treatment. The apparent K_M and v_max values were obtained by curve-fitting to a modified form of the Michaelis-Menten equation (see Materials and Methods). The ATPase activity of Pgp (a,b,c and d) and ABCG2 (e,f,g and h) was stimulated by 40 μM verapamil and 10 μM quercetin, respectively. (*Significant difference compared to control (n = 3, mean ± SEM, ANOVA, Holm-Sidac post-hoc analysis, P < 0.05)).