Figure 5. miR-34a inhibits pancreatic cancer cell proliferation and induces apoptosis by targeting Notch1 expression.

(A) Changes in the cleaved Notch1 protein levels of the cell lines 48 h after transfection with the Notch1-shRNA. Cells were co-transfected with the miR-34a inhibitors and the Notch1-shRNA for 24 h, (B) proliferation was measured by the CCK-8 method, and (C) apoptosis was detected by the FC method. Con control, I the miR-34a inhibitors. *p < 0.05. The full length blots are presented in Supplementary Fig. S6.