. 2017 Jan 18;2017:2730472. doi: 10.1155/2017/2730472

Table 2.

21 signal factors secreted by 3D-MSCs.

Symbol	Form
	Sph-2.5k DC	Sph-2.5k	Sph-6.5k DC	Sph-6.5k	Sph-25k DC	Sph-25k	Sph-50k DC	Sph-50k
	pg/mL
IL-1Ra	0.9 ± 0.1	1.3 ± 0.2	3.0 ± 0.6^∗	3.6 ± 0.4^∗	4.0 ± 0.8^∗	4.4 ± 0.4^∗	4.0 ± 0.6^∗	4.9 ± 0.6^∗
IL-7	57.6 ± 6.0^∗	56.3 ± 6.9^∗	107.5 ± 8.6^∗	126.4 ± 10.5^∗	101.3 ± 9.0^∗	106.2 ± 12.9^∗	106.2 ± 11.0^∗	76.1 ± 7.7^∗
IL-16	2.2 ± 0.4	4.4 ± 1.3	31.5 ± 6.9^∗	45.3 ± 7.6^∗	6.3 ± 1.2	7.9 ± 1.4	13.3 ± 2.5	13.3 ± 2.3
MCP-3	9.4 ± 1.2	12.9 ± 2.0^∗	13.8 ± 2.3^∗	31.8 ± 7.6^∗	10.3 ± 2.0	12.1 ± 3.4^∗	15.6 ± 3.0^∗	18.3 ± 1.8^∗
VEGF	4.2 ± 1.5	7.3 ± 1.4	10.3 ± 2.0	10.3 ± 1.5	12.6 ± 2.7^∗	17.3 ± 2.2^∗	23.5 ± 3.3^∗	30.7 ± 7.6^∗
TGFβ3	9.3 ± 1.5	25.6 ± 6.1^∗	15.8 ± 1.8	37.2 ± 5.1^∗	35.8 ± 5.3^∗	34.2 ± 7.1^∗	35.2 ± 4.8^∗	38.8 ± 5.4^∗
IL-2Rα	8.7 ± 1.9^∗	9.4 ± 1.3^∗	13.3 ± 2.1^∗	14.8 ± 2.2^∗	8.2 ± 1.6^∗	10.3 ± 2.9^∗	9.0 ± 1.4^∗	9.3 ± 1.6^∗
IL-6	5101.0 ± 228.7^∗	5205.5 ± 260.9^∗	5659.4 ± 291.6^∗	5960.3 ± 204.3^∗	5474.62 ± 266.6^∗	5497.0 ± 234.5^∗	5332.4 ± 257.7^∗	5349.0 ± 313.2^∗
MCP-1	150.3 ± 17.8^∗	150.4 ± 15.0^∗	150.8 ± 20.6^∗	150.1 ± 21.9^∗	162.3 ± 30.0^∗	203.6 ± 35.6^∗	150.5 ± 18.3^∗	156.6 ± 24.1^∗
LIF	15.0 ± 1.3^∗	15.2 ± 1.0^∗	14.7 ± 0.7^∗	15.2 ± 2.2^∗	15.7 ± 1.6^∗	22.0 ± 5.0^∗	14.6 ± 2.4^∗	20.9 ± 6.1^∗
G-CSF	240.1 ± 19.4^∗	245.6 ± 18.4^∗	253.2 ± 18.9^∗	323.2 ± 75.0^∗	263.5 ± 19.9^∗	1053.4 ± 162.3^∗	261.4 ± 26.3^∗	346.2 ± 27.2^∗
SDF-1α	86.8 ± 6.2^∗	89.5 ± 7.5^∗	89.5 ± 8.7^∗	164.5 ± 16.2^∗	88.6 ± 7.6^∗	86.6 ± 8.4^∗	117.8 ± 18.4^∗	119.3 ± 11.8^∗
TGFβ1	285.9 ± 25.1^∗	195.1 ± 13.6^∗	199.3 ± 13.4^∗	187.0 ± 13.9^∗	143.0 ± 21.3^∗	125.3 ± 12.9^∗	109.7 ± 12.7^∗	99.4 ± 11.5^∗
TGFβ2	11.1 ± 3.5^∗	10.7 ± 2.8^∗	16.7 ± 1.5^∗	12.4 ± 2.9^∗	17.2 ± 1.3^∗	16.4 ± 1.7^∗	17.2 ± 2.3^∗	12.6 ± 3.2^∗
IL-1α	11.3 ± 3.4	19.9 ± 3.1	7.3 ± 2.0	7.5 ± 1.4	10.2 ± 2.3	12.5 ± 2.9	7.2 ± 2.1	8.7 ± 2.5
IL-1β	7.3 ± 1.6^∗	8.2 ± 1.8	8.2 ± 2.1	6.3 ± 2.0^∗	14.2 ± 2.8	18.4 ± 2.2	22.1 ± 4.3	22.4 ± 4.0
IL-8	2155.5 ± 70.8^∗	1006.9 ± 242.4^∗	4741.2 ± 107.0^∗	4791.4 ± 232.7^∗	4741.2 ± 166.9^∗	4059.8 ± 162.5^∗	6795.4 ± 314.2	7495.1 ± 337.2
GROα	1804.3 ± 212.2	1862.0 ± 211.3	2503.2 ± 160.0	2648.0 ± 226.3	1985.0 ± 287.4	1751.6 ± 197.7	2045.0 ± 227.5	2435.6 ± 249.0
HGF	65.2 ± 5.9	78.3 ± 10.1	65.0 ± 10.4	45.5 ± 7.1^∗	94.0 ± 10.2	92.2 ± 8.8	86.2 ± 8.2	73.0 ± 5.7
bFGF	275.1 ± 17.6^∗	344.1 ± 24.4	293.5 ± 29.3^∗	164.7 ± 23.0^∗	416.3 ± 16.1	200.6 ± 27.9^∗	328.6 ± 11.4	196.4 ± 16.5^∗
SCGF-β	223.4 ± 19.9	230.8 ± 17.9	240.3 ± 29.0	255.4 ± 26.2	284.3 ± 19.1	221.2 ± 22.3	279.4 ± 25.5	268.5 ± 26.9

Data presented as mean ± standard deviation.

^∗ p < 0.05 between 2D-MSCs and certain 3D-MSCs groups.