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. 2017 Feb 1;7:40919. doi: 10.1038/srep40919

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Copyright © 2017, The Author(s)

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(A) 23–25 month old C57BL/6 mice were sacrificed and body/organ weights were measured and plotted as mean ± SEM. Male: Grp78^+/+ (n = 13); Grp78^+/− (n = 18); female: Grp78^+/+ (n = 11); Grp78^+/− (n = 11). *unadjusted P < 0.05, ***unadjusted P < 0.001. (B). Representative histological sections of lung and renal cortex of the indicated genotypes. Both organs show normal tissue architecture. Lungs of GRP78^+/+ and GRP78^+/− mice show unremarkable alveolar spaces (a) of normal sizes and lined by alveolar septae of similar and normal thickness. Bronchioles (b) are lined by respiratory epithelium. The kidneys show glomeruli (arrows) with normal cellularity and unremarkable renal tubules. Magnification bars: 100 microns.