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. 2017 Feb 1;7:40919. doi: 10.1038/srep40919

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(A) Section of spleen from a Grp78^+/+ mouse showing extensive infiltration by a lymphoma outlined by the dashed lines; the inset shows a magnified representative section of the tumor, illustrating a monoclonal population of cells with pleomorphic nuclei and a high mitotic rate. (B) Section of liver from a Grp78^+/− mouse showing an adenoma outlined by the dashed line. Sections of lung from Grp78^+/+ (C) and Grp78^+/− (D) mice. In each case the pulmonary parenchyma is infiltrated by an adenocarcinoma, which is extensive in (C) and microscopic in (D). Both tumors show papillary architecture. Tumors in panels A and D are from C57BL/6 mice while those in panels B and C are from C57BL/6*129sv mice. Magnification bars: 50 microns in A, 100 microns in (B–D).