Figure 1.

The FGFR signaling pathway. (a) Schematic of the structure of FGF receptors and the binding specificities of the FGF ligands. (b) Depiction of the FGFR downstream signalling. HS: heparan sulfate; PIP2: phosphatidylinositol 4,5-bisphosphate; IP3 inositoltriphosphate; PLCγ: phospholipase C; DAG: diacylglycerol; GRB2: growth factor receptor-bound protein 2; GAB1: GRB2 associated binding protein 1; Sos: son of sevenless; MEK: MAPK/ERK kinase; MAPK: mitogen activated protein kinase; STAT: signal transducer and activator of transcription; TFs: transcription factors.