(a) Gelatinase bands in the zymograms of Figure 2 were quantified by densitometry and activity expressed as gel band area per µg protein (4 controls and 4 AD donors). Level of HMW1 in the homogenate of AD samples showed a significant reduction compared to controls. AD, Alzheimer's disease; NDet, not detected; ^∗p < 0.05.

MMP species	MMP activity (gel band area/μg protein) mean ± SD
	Homogenate		Supernatant
	Control	AD	Control	AD
HMW2	35.9 ± 24.2	35.5 ± 7.7	14.7 ± 13.2	10.4 ± 1.8
HMW1	6.4 ± 3.8	1.8 ± 2.0∗	8.3 ± 3.2	6.9 ± 5.0
Pro-MMP9	65.7 ± 48.6	51.8 ± 20	108 ± 75	111 ± 37
Pro-MMP2	NDet	NDet	2.33 ± 1.2	2.7 ± 0.4