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. 2017 Feb 1;4(1):ENEURO.0364-16.2017. doi: 10.1523/ENEURO.0364-16.2017

Fig. 5.

Fig. 5.

Persistent inflammatory injury does not establish tonic nicotinic cholinergic signaling in the rostral ventromedial medulla. In rats that received an intraplantar injection of CFA 2 weeks earlier, microinjection of 5 μg DHβE (☐, n = 6) or 1 μg MLA (▵, n = 6) did not alter either heat hyperalgesia in the ipsilateral, inflamed hind paw (A) or antinociception in the contralateral, uninflamed hind paw (B) compared to saline (●, n = 8). Data are mean ± SEM. BL1 refers to paw withdrawal latency before and BL2 refers to paw withdrawal latency after injection of CFA. **p < 0.01 compared with BL2 values. Two-way repeated-measures ANOVA followed by Holm–Sidak test.