Table 3.

Multivariate Cox regression analysis for OS of 142 patients with NPC

Characteristic	Overall Survival			Relapse-Free Survival
	HR	95% CI	P value	HR	95% CI	P value
Gender
Male vs. Female	0.225	0.053–0.950	0.042*	0.247	0.075–0.819	0.022*
Age (y)
< 46 vs. ≥46	1.389	0.673–2.867	0.374	2.099	1.027–4.293	0.042*
Tumor size
T1 + T2 vs. T3 + T4	0.873	0.292–2.611	0.809	0.972	0.325–2.905	0.959
Lymphoid nodal states
N0-1 vs. N2-3	2.312	0.969–5.519	0.050*	2.662	1.146–6.187	0.023*
Clinical Stage
1 + 2 vs. 3 + 4	0.798	0.327–1.945	0.619	0.856	0.284–2.579	0.783
Local-regional relapse
Yes vs. NO	2.296	1.013–5.204	0.047*	23.877	9.554–59.668	0.000*
Metastasis
Yes vs. No	9.085	1.871–44.128	0.006*	5.045	1.195–21.288	0.028*
WHO histological classification
NKUC vs. NKDC	0.680	0.148–3.121	0.620	0.580	0.129–2.609	0.477
EA
≤ 1:10 vs. >1:10	0.568	0.234–1.381	0.212	0.679	0.275–1.677	0.401
VCA
≤ 1:40 vs. >1:40	0.613	0.207–1.816	0.377	0.376	0.131–1.084	0.070
IGFBP-1
Low vs. High	0.802	0.330–1.947	0.626	0.520	0.213–1.267	0.150
IGF-1
Low vs. High	1.649	0.612–4.443	0.323	1.450	0.602–3.490	0.407
IGFBP-1/IGF-1
> 1 vs. ≤1	0.298	0.096–0.920	0.035*	0.334	0.115–0.969	0.044*