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. 2017 Feb 1;15:9. doi: 10.1186/s12964-017-0164-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — TCTP protein levels increase significantly in the early stages of human colon cancer development. a Immunohistochemical staining with an anti-TCTP antibody of paraffin-embedded tumour samples from colon cancer patients with confirmed adenomas (C , D), non-metastatic (E, F) or metastatic adenocarcinomas (G, H). Areas from surrounding normal colon were used as a control (A, B). Representative examples are shown for each group at 80 × and 400 × magnification. b Graph showing the average TCTP scoring for each patient group, normalised to TCTP levels in normal colon tissue (*P = 0.052; **P = 0.001; ***P < 0.001). c Graph representing the score distribution for each patient group (see Methods for scoring)