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. 2017 Jan 31;17:110. doi: 10.1186/s12879-016-2173-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Parasite DNA clone number, area under curve of number of DNA clones versus time, and elimination kinetics of parasite DNA clones in age-, pre-treatment parasitaemia- and same treatment-matched malarious children with (1) and without (2) ERAP treated with artesunate-amodiaquine. Panel a shows increase in parasite DNA clones from one to five 1 h post-initiation of treatment. Parasite DNA clearance time was 48 h. Panel b shows stable number of DNA clone (one at all times) pre- and post-initiation of treatment and no change in parasite DNA clone number following treatment. Parasite DNA clearance time was 24 h. Panels c and d show area under curve of number of clones versus time in children with and without ERAP, respectively. Panel e and f show monoexponential terminal elimination of DNA clones in children with and without ERAP, respectively. Note: Declines in DNA clone numbers were monoexponential