Table 4.

Factors influencing the kinetics of release of asexual parasites in children with early rising asexual parasitaemia

Variables		Lag time [Mean (95% CI)] (h)	P value	t½rls [Mean (95% CI)] (h)	P value
Age	<5 years (n = 36) v	0.3 (0.2–0.3) v	0.17	1 (0.7–1.2) v	0.42
	≥5 years (n = 169)	0.2 (0.18–0.2)		1 (0.9–1.1)
Gender	Male (n = 116) v	0.2 (0.17–0.2) v	0.21	1.1 (1–1.3) v	0.02
	Female (n = 89)	0.2 (0.2–0.3)		0.9 (0.8–1)
Duration of illness	≤2 days (n = 61) v	0.2 (0.2–0.3) v	0.38	0.9 (0.8–1) v	0.02
	>2 days (n = 117)	0.2 (0.2–0.3)		1.1 (0.9–1.2)
Enrolment parasitaemia	≤100000 μL−1 (n = 40) v	0.2 (0.1–0.3) v	0.43	1 (0.8–1.3) v	0.98
	>100000 μL−1 (n = 165)	0.2 (0.2–0.3)		1 (0.9–1.1)
Enrolment temperature	≤37.4 °C (n = 51) v	0.3 (0.2–0.3) v	0.21	1 (0.7–1.2) v	0.4
	>37.4 °C (n = 154)	0.2 (0.18–0.2)		1 (0.9–1.1)
Haematocrit	<30% (n = 49) v	0.2 (0.2–0.3) v	0.54	1.1 (0.9–1.3) v	0.22
	≥30% (n = 156)	0.2 (0.2–0.3)		1 (0.9–1.1)
Fever clearance time	≤1 days (n = 140) v	0.2 (0.2–0.3) v	0.33	1 (0.9–1.1) v	0.43
	>1 days (n = 14)	0.2 (0.1–0.2)		0.9 (0.7–1.1)
Parasite clearance time	≤1 days (n = 144) v	0.25 (0.21–0.28) v	0.01	0.8 (0.7 – 0.8) v	<0.0001
	>1 days (n = 61)	0.18 (0.14–0.21)		1.6 (1.4–1.8)

t _½rls half-time of release of asexual parasitaemia into peripheral blood, v versus