Table 5.

Parameters for disposition of asexual parasitaemia in children with or without early rising asexual parasitaemia following artemisinin-based combination treatments

Parameters	Early rising asexual parasitaemia			P value
	Yes (n = 205)	No (n = 211)	All (n = 416)
Cmaxpd (μL−1)
Geometric mean	91,502	61,639	74,887	0.01
Range	3,465-838,500	1,800-1,096,636	1,800-1,096,636
Tmaxpd (h)
Mean	2.6	0.2	1.4	<0.0001
95% CI	2.3–2.9	0.1–0.3	1.2–1.6
AUCpd (μL−1.h)				<0.0001
0-4 h (Geometric mean)	2.6 × 105	1.5 × 105	2.0 × 105
Range	1.0 × 104–3.1 × 106	1.6 × 103–2.2 × 106	1.6 × 103–3.1 × 106
0–8 h (Geometric mean)	5.3 × 105	2.7 × 105	3.9 × 105	0.001
Range	2.0 × 104–5.9 × 106	2.2 × 103–2.4 × 106	2.2 × 103–5.9 × 106
0–24 h (Geometric mean)	7.8 × 105	3.6 × 105	5.3 × 105	<0.0001
Range	2.9 × 104–1.1 × 107	2.7 × 103–4.1 × 106	2.7 × 103–1.1 × 107
0–48 h (Geometric mean)	7.9 × 105	3.7 × 105	5.4 × 105	<0.0001
Range	2.9 × 104–1.1 × 107	2.7 × 103–4.5 × 106	2.7 × 103–1.1 × 107
0–∞ (Geometric mean)	8.0 × 105	3.7 × 105	5.4 × 105	<0.0001
Range	2.9 × 104–1.1 × 107	2.7 × 103–4.5 × 106	2.7 × 103–1.1 × 107
CLBpd (Lh−1)
Mean	0.1	0.4	0.3	<0.0001
95% CI	0.1–0.2	0.3–0.4	0.2–0.3
Elimination half-time (h)
Mean	1.2	1.2	1.2	0.6
95% CI	1.1–1.3	1.1–1.2	1.1–1.2
Elimination rate constant (h−1)
Mean	0.6	0.6	0.6	0.9
95% CI	0.6–0.7	0.6–0.7	0.6–0.7

h hour, C _maxpd maximum asexual parasite density (concentration), T _maxpd time to reach maximum asexual parasite density (concentration), CL _Bpd volume of blood cleared of parasitaemia per unit of time, AUC _pd area under curve of plot of parasite density (parasitaemia) versus time