Table 6.

Features of children with or without early rising asexual parasitaemia matched for gender, enrolment parasitaemia, treatment and same day presentation who were treated with artesunate-amodiaquine, artemether-lumefantrine or dihydroartemisinin-piperaquine

	Early rising asexual parasitaemia			P value
	Yes (n = 85)	No (n = 85)	ALL (n = 170)
Temperature (°C)
Mean	38.3	38	38.1	0.07
95% CI	38.1–38.6	37.7–38.3	37.9–38.3
Fever on day 1	9	5	14	0.27
Fever clearance time (day)
Mean	1.1 (n = 66)	1.1 (n = 52)	1.1 (n = 118)	0.59
95% CI	1–1.2	1–1.2	1–1.1
Geometric mean parasitaemia (μL−1)
At enrolment (0 h)	61,165	59,853	60,505	0.96
Range	2,928–536,912	2,000–500,000	2,000–536,912
1 h	74,268	39,865	55,059	0.001
Range	2, 136–763,500	790–314,030	790–763,500
2 h	71,410	30,689	46567	<0.0001
Range	2,976–838,500	284–313,980	284–838,500
4 h	57,650	24,043	38,394	<0.0001
Range	210–785,610	339–253,304	210–785,610
6 h	33,950	9,604	18,312	0.02
Range	980–531,000	321–133,400	321–531,000
8 h	37,017	8,052	16,919	0.002
Range	656–616,119	106–266,400	106–616,119
Parasite positivity
On day 1 [%]	18 [21]	13 [15]	31 [20]	0.32
On day 3 [%]	1 [1]	1 [1]	2 [1]	1.0
PRRD1
Geometric mean	1.6 × 104	2.7 × 104	2.1 × 104	0.68
Range	6.5 × 10−1–5.4 × 105	9.8 × 100–5.0 × 105	6.5 × 10−1–5.4 × 105
PRRD2
Geometric mean	6.1 × 104	5.6 × 104	5.9 × 104	0.78
Range	2.9 × 103–5.4 × 105	6.0 × 102–5.0 × 105	6.0 × 102–5.4 × 105
Parasite clearance time (day)
Mean	29.6	28.5	29.1	0.53
95% CI	27–32.3	26.1–30.9	27.3–30.9
Anaemia on day 1	29	22	51	0.22
Anaemia recovery time (day)
Mean	13.2 (n = 21)	10.6 (n = 24)	11.6 (n = 44)	0.25
95% CI	10.5–15.9	6.8–14.4	9.2–13.9
No. with late-appearing anaemia	12	9	21	0.64

H hour, PRR _D1 parasite reduction ratio 1 day after treatment began, PRR _D2 parasite reduction ratio 2 days after treatment began, CI confidence interval