Table 4.

HLA-G genotype, allele and haplotype frequencies in patient sub groups

	Healthy Siblings (126) n (%)	RF 10 n (%)	OR (95% CI)	pc	MVL 67 n (%)	OR (95% CI)	pc	CVL 22 n (%)	OR (95% CI)	pc
14 bp Ins/Del
Genotypes
Ins/Ins	27 (21.4)	2 (20.0)	0.92 (0.18-4.57)	0.7680	9 (13.4)	0.57 (0.25-1.29)	0.2446	5 (22.7)	1.08 (0.36-3.19)	0.8854
Del/Del	36 (28.6)	2 (20.0)	0.62 (0.13-3.09)	0.8294	24 (35.8)	1.39 (0.74-2.62)	0.3829	9 (40.9)	1.73 (0.68-4.40)	0.3630
Ins/Del	63 (50.0)	6 (60.0)	1.5 (0.40-5.57)	0.7792	34 (50.8)	1.03 (0.57-1.86)	0.9581	8 (36.4)	0.57 (0.22-1.46)	0.3421
Alleles
Ins	117 (46.4)	10 (50.0)	1.15 (0.46-2.86)	0.9399	52 (38.8)	0.73 (0.48-1.12)	0.1837	18 (40.9)	0.80 (0.42-1.53)	0.6070
Del	135 (53.6)	10 (50.0)	0.87 (0.35-2.15)	0.9399	82 (61.2)	1.37 (0.89- 2.09)	0.1837	26 (59.1)	1.25 (0.65-2.40)	0.6070
+3142 C/G
Genotypes
C/C	6 (4.8)	0	0	0.9250	7 (10.5)	2.33 (0.75-7.25)	0.2306	5 (22.7)	5.88 (1.62-21.39)	0.0116 a
G/G	66 (52.4)	4 (40.0)	0.61 (0.16-2.25)	0.6705	34 (50.7)	0.94 (0.52-1.69)	0.9481	10 (45.5)	0.76 (0.30-1.89)	0.7124
C/G	54 (42.8)	6 (60.0)	2.0 (0.54-7.44)	0.4714	26 (38.8)	0.84 (0.46-1.55)	0.6962	7 (31.8)	0.62 (0.24-1.63)	0.4618
Alleles
C	66 (26.2)	6 (30.0)	1.21 (0.44-3.27)	0.9136	40 (29.9)	1.20 (0.75-1.90)	0.5174	17 (38.6)	1.78 (0.91-3.46)	0.1300
G	186 (73.8)	14 (70.0)	0.83 (0.30-2.24)	0.9136	94 (70.1)	0.83 (0.52-1.33)	0.5174	27 (61.4)	0.56 (0.29-1.10)	0.1300
Haplotypes
Ins/G	117 (46.4)	10 (50.0)	1.15 (0.46-2.86)	0.9399	52 (38.8)	0.73 (0.48-1.12)	0.1837	18 (40.9)	0.80 (0.42-1.53)	0.6070
Del/G	69 (27.4)	4 (20.0)	0.66 (0.21-2.05)	0.6491	42 (31.3)	1.21 (0.76-1.91)	0.4835	9 (20.5)	0.68 (0.31-1.49)	0.4372
Del/C	66 (26.2)	6 (30.0)	1.21 (0.44-3.27)	0.9136	40 (29.9)	1.19 (0.75-1.91)	0.5174	17 (38.6)	1.78 (0.91-3.46)	0.1300

RF- Rheumatic Fever, MVL-Mitral Valvular Lesions, CVL-Combined Valvular Lesions, CI-confidence interval, OR-odds ratio, p_c-Yates corrected p value

a - χ ² = 6.3692, Fisher Exact P (P_f) = 0.0117

Bold - significant p value (<0.05)