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. 2017 Feb 1;5:11. doi: 10.1186/s40478-017-0416-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — AAV1/2-A53T-aSyn SN develop insoluble pSer129 aSyn with Lewy-like pathology. There was no positive immunostaining for pSer129 aSyn in human control nigra (a). In contrast, in animals injected with AAV1/2-A53T-aSyn there was a strong signal for pSer129 aSyn in the SN of the ipsilateral hemisphere including several densely labelled cells (b). Human PD nigral Lewy bodies stained with the same method are provided for comparison (c). Similarly, several structures were noted in mouse brain (d) with morphology consistent with Lewy neurites in human PD brain (e)