Table 1.

Pretreatment and posttreatment values of clinical parameters of the patients for each treatment group

	LIRA3	N = 14		LIRA1.2 + MET2000	N = 14		Comparison of pretreatment values between groups
Characteristic	Pretreatment	Post treatment	P a	Pretreatment	Post treatment	P a	P b
Age (years)	34.6 ± 6.1			31.6 ± 5.9			0.164
Weight (kg)	111.1 ± 14.8	104.7 ± 14.8	0.001	102.5 ± 9	98.9 ± 10.3	0.002	0.137
BMI (kg/m2)	39.2 ± 5.5	37.0 ± 5.5	0.001	37.5 ± 5.3	36.2 ± 5.5	0.002	0.482
Waist circumference (cm)	110.1 ± 12	105.9 ± 12.8	0.003	105.2 ± 10.7	103.0 ± 8.2	0.113	0.265
Androstenedione (nmol/l)	7.0 ± 3.7	7.7 ± 3.4	0.451	10.6 ± 6.4	8.6 ± 3.5	0.530	0.094
Total testosterone (nmol/l)	1.3 ± 0.7	1.2 ± 0.5	0.065	1.8 ± 0.9	1.5 ± 0.8	0.023	0.125
Free testosterone (pmol/l)	9.1 ± 5.1	9.7 ± 3.8	0.594	11.7 ± 5.7	11.0 ± 4.2	0.660	0.164
SHBG (nmol/l)	39.6 ± 41.4	46.9 ± 54.5	0.018	27.7 ± 21.1	47.2 ± 90.4	0.430	0.137
Glu 0 min OGTT (mmol/l)	5.2 ± 0.4	5.1 ± 0.4	0.341	5.4 ± 0.6	5.0 ± 0.3	0.015	0.635
Glu 120 min OGTT (mmol/l)	5.9 ± 1.0	4.7 ± 0.7	0.002	7.1 ± 2.0	5.9 ± 1.6	0.016	0.178
Insulin 0 min OGTT (mU/l)	22 ± 11.7	19.4 ± 10.4	0.272	24.5 ± 18.4	16.8 ± 13.2	0.035	0.839
Insulin 120 min OGTT (mU/l)	86.4 ± 40.3 [2]	68.9 ± 58.4	0.008	118.8 ± 87.5	109.1 ± 127.0	0.551	0.631
HOMA IR	5.1 ± 2.9	4.4 ± 2.4	0.272	5.9 ± 4.3	3.7 ± 3.0	0.013	0.910
Cholesterol (mmol/l)	4.8 ± 0.8	4.8 ± 0.8	0.875	4.9 ± 1.1 [1]	4.5 ± 1.0 [1]	0.107	0.720
HDL cholesterol (mmol/l)	1.3 ± 0.3	1.2 ± 0.3	0.194	1.3 ± 0.1 [1]	1.3 ± 0.2 [1]	0.627	0.239
LDL cholesterol (mmol/l)	2.9 ± 0.8	3.0 ± 0.7	0.928	3.0 ± 0.9 [1]	2.7 ± 0.9 [1]	0.049	0.905
TG (mmol/l)	1.5 ± 0.7	1.6 ± 0.6	0.727	1.4 ± 0.7 [1]	1.2 ± 0.5 [1]	0.075	0.550

data are expressed as mean ± SD

^acompared with Wilcoxon signed-rank test for related samples, bold values indicate statistically significant differences

^bcompared with nonparametric Mann–Whitney test