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. 2017 Jan 31;3(1):e129. doi: 10.1212/NXG.0000000000000129

Figure 4. Kainate receptors bearing the GluK2 subunit are constitutively active.

Figure 4

(A) Amplitude of holding current at −70 mV for HEK293T/17 cells expressing homomeric GluK2(A567T) kainate receptors (KARs) (left panel), GluK2(A657T)/Neto2 (middle panel), or heteromeric GluK2(A657T)/GluK5 KARs (right panel). (B) Representative traces demonstrating the change in holding current after a 1-second application of 20 μM NASPM in cells expressing homomeric GluK2(A657T) KARs (left panel, n = 4), GluK2(A657T)/Neto2 KARs (middle panel, n = 4), or heteromeric GluK2(A657T)/GluK5 KARs (right panel, n = 4). NASPM = 1-naphthyl acetyl spermine trihydrochloride.