Fig. 7.

Silencing DCLK1 and pro-survival signaling reduced the survival ability of human DLD1 & HT29 colon cancer cells. a Colony formation ability of DLD1 and HT29 cells after the knockdown of DCLK1, NOTCH1, and RELA; bar graph represents the average number of colonies formed from DLD1 and HT29 cells after the knockdown of DCLK1, NOTCH1, and RELA. b In vitro invasion and migration of DLD1 cells after the knockdown of DCLK1, NOTCH1, and RELA; bar graph represents the number of cells migrated and invaded after the knockdown of DCLK1, NOTCH1, and RELA. c In vitro invasion and migration of HT29 cells after the knockdown of DCLK1, NOTCH1, and RELA, bar graph represents the number of cells migrated and invaded after the knockdown of DCLK1, NOTCH1, and RELA. All quantitative data are expressed as means ± SD of a minimum of three independent experiments. P values of <0.05 were considered statistically significant