TABLE 2.
Sabaeus African green monkey candidate coreceptorsa
| AGM Sab 7TMR | % amino acid identity to 7TMR from: |
No. of amino acids differing from human sequence |
|||
|---|---|---|---|---|---|
| Human | Rhesus macaque | Sooty mangabey | NTD | ECL2 | |
| APJ | 98.7 | 99.7 | 99.5 | 0 | 1 |
| CCR2b | 96.7 | 99.2 | 99.4 | 2 | 2 |
| CCR3 | 93.5 | 98 | 97.2 | 6 | 4 |
| CCR4 | 98.6 | 100 | 100 | 0 | 1 |
| CCR5 | 97.4 | 99.1 | 98.9 | 2 | 1 |
| CCR8 | 94.6 | 99.2 | 98.9 | 8 | 1 |
| CXCR4 | 98.6 | 100 | 99.7 | 3 | 1 |
| CXCR6 | 95.3 | 98.8 | 98.3 | 6 | 1 |
| GPR1 | 98 | 100 | 99.7 | 1 | 1 |
| GPR15 | 97.2 | 99.4 | 99.4 | 1 | 2 |
a
Seven-transmembrane receptors (7TMRs) were cloned from PBMC genomic DNA or cDNA, and the amino acid identity compared to human, rhesus macaque, and sooty mangabey molecules is shown. Also shown is the number of amino acids differing from the sequence of the human molecule in the N-terminal domain (NTD) and extracellular loop 2 (ECL2), which are implicated in coreceptor function based on studies with CCR5.