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Rapamycin inhibits IgG responses in protein and Ad5 immunization models. B6 mice were immunized with either NP-KLH (precipitated in alum) (A) or Ad5 (B). Rapamycin was injected intraperitoneally daily for 30 days. Serum was harvested on the indicated days, and the antigen-specific IgG titer was quantified by ELISA. Graphs show means and SEM (n = 5 mice/time point for each group). Data representative of two independent experiments are presented.
