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The RPLP1/2 heterodimer is required for efficient production of infectious DENV-2 and YFV. (A) Titers for supernatants from HuH-7 or A549 cells infected with DENV-2 were determined in Vero cells. (B) The same experiments as show in panel A, except with YFV. Statistical significance was assessed by a two-tailed Student's t test between NSC and experimental siRNAs. *, P < 0.05; **, P < 0.01, ***, P < 0.001.
