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Sensitivity of DLBCL cell lines to GSK-J4. (A) WST-1 assay showing drug concentration-dependent effects of GSK-J4 (0.5–5 μM) on proliferation of DLBCL cell lines, Karpas-422, DB, Pfeiffer, OCI-Ly4, OCI-Ly1, OCI-Ly8, Toledo, SU-DHL-6, SU-DHL-8. (B) Sub-G1 apoptosis analysis of GSK-J4 (1.5 μM) induced cell death in sensitive DLBCL cell lines and fresh DLBCL patients’ samples (n=3). Apoptosis rates were compared to those of buffer-treated controls.
