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Effect of treatment discontinuation. Summary of observations in 6 patients who discontinued rapamycin treatment. (A) Status of rapamycin treatment is indicated by [−]/[+]. The spleen size is indicated as follows: − not palpable; + palpable but <5 cm; ++ >10 cm or up to umbilicus. °Additional lymphadenopathy. *Cytopenia. (B) Percentages of DNT cells (left y-axis, black circles) and sFASL levels (right y-axis, open boxes/broken lines) at different stages of therapy.
