Figure 1.

CXCL8 and G-CSF plasma concentrations in cynomolgus monkeys during the 39 week dosing interval. Samples of venous whole blood taken into K3-EDTA anticoagulant were obtained from conscious male (open bars) and female monkeys (closed bars) at week 26 (panels A & C) and week 32 (panels B & D). CXCL8 and G-CSF levels in samples collected at the end of compound treatment (week 40) were generally comparable to those obtained for week 32 (data not shown). Cytokine levels were determined by multiplex bead array (Millipore). Results are expressed as mean ± S.D. n=8 monkeys per treatment group. *P<0.05 and **P<0.01 vs. concurrent vehicle-treated animals (0 mg/kg/day) as determined by Shirley’s nonparametric test. IL-8: interleukin-8; G-CSF: granulocyte colony-stimulating factor.