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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Clin Cancer Res. 2014 Jul 21;20(18):4837–4848. doi: 10.1158/1078-0432.CCR-14-0885

Figure 1.

Figure 1

Top predictive markers of pathological response in patients treated with taxane/anthracycline based therapies: A, gene expression data were mined to define genes with the top-ranked ROC characteristics in cases treated with TA and TFAC. The top 20 genes and their associated AUC values are shown for two cohorts. B, gene ontology analysis was performed on the top 150 predictive genes identified in each cohort. C, the indicated gene expression signatures were used to cluster cases based on signature expression value. The Kolmogorov–Smirnov (KS) statistic was used to determine the association of the signature value with clinical response. D, ROC curves of the indicated gene signatures that are enriched for cell-cycle/proliferation associated genes.