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. 2017 Jan 1;31(1):34–45. doi: 10.1101/gad.289728.116

Figure 2.

Figure 2.

The PIDDosome is required to activate p53 after cytokinesis failure. A549 CASP2, PIDD1, or RAIDD knockout cells obtained using two different small guide RNAs (sgRNAs) were treated with ZM447439 for either 24 h and processed for immunoblotting (A) or up to 72 h and processed for DNA content analysis (B). hTERT-RPE1 cells were transduced with the indicated constructs targeting either mouse CD8 (mCD8) as a negative control or RAIDD and then treated with ZM447439 for either 24 h and processed for immunoblotting (C) or up to 72 h and processed for DNA content analysis (D).