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. 2017 Jan 1;31(1):34–45. doi: 10.1101/gad.289728.116

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© 2017 Fava et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 4. — The PIDDosome constrains hepatocyte polyploidization in vivo via p53. (A) Hepatocytes were isolated by collagen perfusion of 7-wk-old mice of the indicated genotypes and subjected to DNA content analysis. (B) Quantification of the DNA content distribution for each genotype displayed in A. Bars represent mean percentages ± SEM. n = 3–5. (C) DNA content analysis and immunoblotting for hepatocytes obtained from animals of the indicated genotypes either unweaned (−) or weaned (+) at the age of 20 and 25 d, respectively. (D) Quantification of the DNA content distribution for each genotype displayed in C. n = 3. (*) P < 0.05; (**) P < 0.01; (***) P < 0.001 using unpaired Student's t-test.