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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: J Endocrinol. 2016 Oct 31;232(2):137–153. doi: 10.1530/JOE-16-0370

Figure 1.

Figure 1

Impaired endurance capacity in Chga-KO mice. (A) Increased body weight in Chga-KO mice. (B) GAS muscle weight is decreased in Chga-KO mice. (C) The VO2 maximal speed in an incremental treadmill running test in WT and Chga-KO mice. (D) Endurance exercise capacity was evaluated by the time to reach exhaustion when mice were run at 60% of the average VO2 maximal speed. Supplementation of Chga-KO mice with CgA for 15 days restored endurance capacity. (E) Maximal speed. (F) Endurance exercise capacity. Expressions of CgA/Chga in GAS muscle. (G and H) Western blot showing expression of CgA in GAS muscle in WT mice and no expression in Chga-KO (KO) mice. (I) Expression of Chga in WT and Chga-KO mice. Expressions of Chga, Chgb and Scg2 genes in GAS muscle (J), adrenal gland (K), pituitary gland (L), hypothalamus (M) and pancreatic islets (N).