Table 1.

Physiological assessments for age and treatment groups.

	Young		Middle-age		Old
	Control	Metformin	Control	Metformin	Control	Metformin
Body weight at the start of the study (g)	27.85 ± 0.58	26.98 ± 0.35	33.69 ± 0.69*	32.78 ± 0.67*	34.21 ± 0.50*	33.89 ± 0.63*
Body weight at the end of the study (g)	30.36 ± 0.46	29.687 ± 0.47	37.86 ± 1.10*	35.05 ± 0.88*#	34.46 ± 0.68*	33.57 ± 0.75*
Food intake across study duration (g/day)	4.13 ± 0.22	3.57 ± 0.08#	3.98 ± 0.08	3.86 ± 0.09	4.55 ± 0.18*	4.15 ± 0.10*#
Water intake across study duration (ml/day)	4.73 ± 0.42	4.17 ± 0.09	3.93 ± 0.07	3.72 ± 0.08	4.62 ± 0.27	4.44 ± 0.28
Percent change in blood glucose from the start to the end of the study (mg/dl)	-3.99 ± 7.47	-0.65 ± 6.80	-11.17 ± 4.59	2.95 ± 6.69	-9.92 ± 5.26	-4.85 ± 5.71
Calculated daily metformin dose (mg/kg)	0	298.7	0	219.0	0	259.6

Each value represents the mean ± SE of young (5 mo), middle-aged (13 mo), or old (24 mo) mice.

^*significantly different from treatment-matched young, p<0.05

^#significantly different from age-matched controls, p<0.05