Table 2.

Effects of age and metformin treatment on simple reflexes and spontaneous locomotor activity

	Young		Middle-age		Old
	Control	Metformin	Control	Metformin	Control	Metformin
Latency to initiate walking (s)	2.13 ± 0.43	2.38 ± 0.31	3.79 ± 0.47*	3.48 ± 0.58	3.36 ± 0.39	4.75 ± 0.56*#
Latency to turn in a dead-end alley (s)	8.82 ± 0.60	11.01 ± 1.66	14.03 ± 2.24	10.75 ± 1.34	16.56 ± 1.96*	18.18 ± 2.57*
Latency to tread (wire suspension) (s)	20.31 ± 3.55	21.75 ± 4.72	46.47 ± 4.30*	44.77 ± 4.35*	52.33 ± 3.04*	49.61 ± 2.94*
Latency to negative geotaxis (s)	2.39 ± 0.73	2.08 ± 0.29	2.34 ± 0.63	1.74 ± 0.17	2.06 ± 0.48	2.26 ± 0.25
Distance traveled (cm)	571.9 ± 36.8	585.9 ± 30.5	526.8 ± 25.9	548.9 ± 26.2	561.6 ± 34.1	624.8 ± 36.3

Each value represents the mean ± SE of 15-18 mice.

^*Significantly different from treatment-matched young, p<0.05

^#Significantly different from age-matched control, p<0.05