Figure 3.

PD-like pathology in the 6-OHDA rat model was attenuated by LLDT8 treatment. (A) IHC staining for TH⁺ neurons in SNpc (as indicated by the dotted bracket). Scale bar = 500 μm. (B) The ratio (left/right) of stereological quantification of numbers of TH⁺ neurons in SNpc after systemic administration of different doses of LLDT8 (31.25, 62.5 and 125 μg/kg) or rasagiline, for 5 weeks. (C) IHC staining for TH⁺ fibers in striatum (STR) treated with LLDT8 for 5 weeks. Scale bar = 2.0 mm. (D) The ratio (left/right) of TH⁺ fiber density in STR after systemic administration of different doses of LLDT8 (31.25, 62.5, and 125 μg/kg) or rasagiline, for 5 weeks. (E) The scan picture of TH⁺ protein and (F) the statistical TH⁺ protein results of all experimental groups treated with LLDT8. Data are shown as mean ± SEM. ^#P < 0.05, ^##P < 0.01 vs. sham, ^*P < 0.05, ^**P < 0.01 vs. vehicle using one-way ANOVA with post hoc LSD t-test, n=4-6.