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. 2017 Jan 30;199(4):e00698-16. doi: 10.1128/JB.00698-16

FIG 4.

FIG 4

Increasing CarD's affinity for RNAP attenuates M. tuberculosis in a mouse model of infection. Dot plot of CFU in the lungs of C57BL/6J mice infected with the ΔcarD attB::tet-carD strain expressing either CarDWT (●), CarDI27F (■), or CarDI27W (▲). Each time point is the means ± the SEM of data from at least six mice per strain. Statistical significance was analyzed by ANOVA and Tukey's multiple-comparison test (**, P ≤ 0.01; ***; P ≤ 0.001). All comparisons were tested, and only significantly different comparisons are shown.