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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Adv Mater. 2016 Sep 12;28(43):9486–9490. doi: 10.1002/adma.201603270

Figure 2.

Figure 2

Effect of LbL coatings on probiotic survival against acid and bile insults. a) Plain, non-layered, BC rapidly die when exposed to simulated gastric fluid at 37 °C. b) Plain, non-formulated, BC rapidly die when exposed to 4% bile salt solution at 37 °C. c) LbL-formulated (CHI/ALG)2 (black bars) BC are protected against both acidic and bile salt insults at 37 °C for up to 2 h. LbL coatings of chitosan (dark gray bars), (CHI/L100)1 (white bars), (CHI/L100)2 (light gray bars), and CHI/ALG)1 (cross-hatched bars) are less effective at protecting BC against both acid and bile insults. Error bars represent standard deviation (n = 3). *denotes statistical difference (P < 0.05) using Student’s t-test between plain and LbL groups. **denotes statistical difference (P < 0.05) using individual Student’s t-test between the designated group and each other group.