Table 1. Examples of up-regulation in leukemic cells by p53, IL-6, or TG of genes that are expressed in different normal tissues.
| p53
|
IL-6
|
TG
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tissues | Gene | GenBank accession no. | Fold | n | Gene | GenBank accession no. | Fold | n | Gene | GenBank accession no. | Fold | n |
| Hematopoietic | Gtse1 | AJ222580 | 11.5 | 22 | Il4ra | M27960 | 15.0 | 13 | Adcy | U12919 | 3.3 | 8 |
| Tap1 | U60020 | 5.7 | Cd53 | X97227 | 4.9 | Hcph | M68902 | 2.8 | ||||
| Neuronal | Ptpro | U37465 | 6.2 | 26 | Snx10 | AI746846 | 3.4 | 1 | Egr2 | M24377 | 9.6 | 8 |
| Pmm1 | AF007267 | 5.9 | Serpini1 | AJ001700 | 7.8 | |||||||
| Muscle | Ak1 | AJ010108 | 35.6 | 11 | Sh3glb1 | AW125190 | 3.8 | 1 | Kpna1 | U20619 | 2.7 | 2 |
| Lpin1 | AI846934 | 12.6 | Mlf1 | AF100171 | 2.0 | |||||||
| Liver | Ccsd | AI839702 | 4.2 | 8 | Sc5d | AB016248 | 2.7 | 3 | Lifr | D17444 | 4.4 | 3 |
| Lypla | AA840463 | 3.3 | Lifr | D17444 | 2.5 | Cp | U49430 | 3.3 | ||||
| Testis | Tcte3 | U21673 | 12.0 | 9 | Taf9 | AI842969 | 2.2 | 3 | Xmr | X72697 | 2.6 | 1 |
| Ppm1b | D45859 | 4.6 | Nphp1 | AJ243223 | 2.5 | |||||||
The genes are examples of up-regulated genes in M1-t-p53 leukemic cells in clusters of genes that are preferentially expressed in normal hematopoietic and nonhematopoietic tissues. Fold up-regulation is from results described by Lotem et al. in ref. 20. All of the genes regulated by p53, IL-6, and TG are shown in Tables 3 and 4.